SPOILER WARNING: This article contains major spoilers for "Option Two," the latest episode of Agents of S.H.I.E.L.D. There are no spoilers for Avengers: Infinity War.
Yes, Agents of S.H.I.E.L.D. did acknowledge the events of Avengers: Infinity War, but maybe not the way you'd expect. In "Option Two," the latest episode, Daisy met up with Tony Caine, aka the Candyman. As he filled her in on a potential way to save Coulson, he casually mentioned the Children of Thanos' attack on New York City.
"Aliens, you know? Have you seen all this weird stuff happening in New York?" he asked.
Daisy didn't even bother to look up at him when he said it. "I can't watch the news. It makes me crazy," she replied -- and that was that.
Of course, Daisy and the rest of S.H.I.E.L.D. have been too busy attempting to stave off an extinction-level event of their own to catch the news. In the beginning of the season, they jumped forward in time to the year 2091. There, they discovered that the world had been cracked apart, and many believed Daisy to be responsible. Since S.H.I.E.L.D. returned to the past, they've actively been trying to find a way to avert the disaster, but their options are limited; they've been constrained to the Lighthouse, as the events of Season 4 made them fugitives. Between that and the rise of Graviton, there may not be much they can do to stop this future from happening.
Though Agents of S.H.I.E.L.D. has mentioned Marvel Cinematic Universe events before, this may be the show's quickest and most dismissive reference to the wider universe. The team helped clean up the University of Greenwich following Thor: The Dark World, aided Nick Fury in acquiring a helicarrier for Avengers: Age of Ultron and a discussion of the fallout from Captain Amercia: Civil War.
The only MCU event to truly impact the show was Captain America: The Winter Soldier, which revealed that Hydra had infiltrated S.H.I.E.L.D. This shook up the core cast of the show, as Grant Ward was outed as a Hydra operative. It also marked the show's turn to a more serialized form of storytelling, which continues today.
Airing Fridays at 9 p.m. ET/PT on ABC, Marvel’s Agents of S.H.I.E.L.D. Season 5 stars Clark Gregg, Ming-Na Wen, Chloe Bennet, Henry Simmons, Ian De Caestecker, Natalia Cordova-Buckley and Elizabeth Henstridge.