What Other Match-Ups “Have” to Happen?

by  in Comic News Comment
What Other Match-Ups “Have” to Happen?

I can honestly say that I never thought that Cap and Doc Ock would be a great match-up or anything like that.

Certainly not so that it would have “had to happen.”

That got me thinking, though – in this day and age of characters being around for so long, what are the most notable match-ups that HAVEN’T happened?

Has Doctor Octopus ever fought Thor or Iron Man? Has Superman ever fought Two-Face or the Penguin? Have the Fantastic Four ever tangled with Loki?

What is the most notable match-up that hasn’t happened yet?