Irrfan Khan and Omar Sy have joined Tom Hanks in "Inferno," director Ron Howard's follow-up to the mystery-thrillers "The Da Vinci Code" and "Angels & Demons."

Like the two Columbia Pictures movies that preceded it, this is an adaptation of author Dan Brown's bestselling novels, which center on Harvard symbologist Robert Langdon. In "Inferno," Langdon (Hanks) awakes in an Italian hospital with amnesia, and must team with Dr. Sienna Brooks (Felicity Jones) to recover his memories and stop a madman from unleashing a global epidemic.

According to The Hollywood Reporter, Khan ("The Amazing Spider-Man," "Jurassic World") will play the leader of a shadowy group that becomes involved with Langdon, while Sy ("X-Men: Days of Future Past," "Jurassic World") has been cast as the head of a disease-prevention team. Sidse Babett Knudsen has also joined the cast as the director of the World Health Organization."Inferno" opens Oct. 14, 2016.