Seth Rogen and Rose Byrne's Mac and Kelly Radner may have thought their troubles had ended with 2014's "Neighbors," but in the first trailer for the sequel, they discover they face an even bigger problem than the boys of Delta Psi: the girls of Kappa Nu.

And who better for them to turn to for help than Zac Efron's Teddy, who arrives ready to "shut this shit down." However, it's clear sorority sisters Chloë Grace Moretz, Kiersey Clemons and Beanie Feldstein aren't planning to go without a fight.

Directed by a returning Nicholas Stoller, "Neighbors 2: Sorority Rising" opens May 20.