FOX has released a new trailer for the finale episode of "The X-Files" Season 10 -- teasing a Mulder-Smoking Man confrontation as the event series comes to a close.

The investigations that Mulder and Scully previously began with conspiracy theorist and web-TV show host Tad O’Malley (guest star Joel McHale) seem to have awakened powerful enemies. A widespread panic begins as people all over the country suddenly start falling gravely ill, and Scully must look within to try and find a cure. Meanwhile, Mulder confronts the man whom he believes to be behind it all, but another figure from Mulder and Scully’s past may prove to be the key to their salvation in the all-new “My Struggle II” Season Finale episode of THE X-FILES airing Monday, Feb. 22 (8:00-9:00 PM ET/PT) on FOX.

The series stars David Duchovny, Gillian Anderson and Mitch Pileggi, alongside guest stars William B. Davis, Annabeth Gish, Joel McHale, Robbie Amell, Lauren Ambrose, Julian Christopher and Aliza Vellani.

"The X-Files" season finale airs Monday, February 22 at 8/7c on FOX.