Sid, Manny and Diego face catastrophe head on in the latest trailer for Blue Sky Studios' "Ice Age: Collision Course."

In the fifth film in the hit animated franchise, Scrat's eternal pursuit of that elusive acorn catapults him into space, where he accidentally sets off a series of cosmic events that threatens the Ice Age World.

Scrat’s epic pursuit of the elusive acorn catapults him into the universe where he accidentally sets off a series of cosmic events that transform and threaten the Ice Age World. To save themselves, Sid, Manny, Diego and the rest of the herd must leave their home and embark on a quest to exotic new lands.

Opening July 22, “Ice Age: Collision Course” features returning stars Ray Romano, Denis Leary, John Leguizamo, Queen Latifah, Seann William Scott, Josh Peck, Simon Pegg, Keke Palmer, Wanda Sykes and Jennifer Lopez. They’ll be joined by Stephanie Beatriz, Adam DeVine, Jesse Tyler Ferguson, Max Greenfield, Jessie J, Nick Offerman, Melissa Rauch, Michael Strahan and Neil deGrasse Tyson.