Courtesy of Marvel Comics, CBR presents an exclusive first look at artist Marcos Martin's variant cover for "Amazing Spider-Man" #648, the first chapter of Dan Slott and Humberto Ramos' "Big Time" storyline.

COVER BY: Humberto Ramos

WRAPAROUND VARIANT COVER BY: Marcos Martin

WRITER: Dan Slott

PENCILS: Humberto Ramos

The Story: BIG TIME BEGINS! Big changes are happening for the Amazing Spider-Man: Bigger threats, bigger guest-stars, and a big opportunity that could turn Peter Parkers life around! Which cast members are staying and whos saying goodbye? Find out as were introduced to new characters and reintroduced to a number of Spidey villains as they make the triumphant return to the book! Plus: New developments for Mayor J. Jonah Jameson, the staff at Front Line, and The Sinister Six! The next chapter in Spider-Man history starts here! Guest starring THE AVENGERS and THE FANTASTIC FOUR in a giant-sized, 39 page lead feature! PLUS! An All-New Adventure featuring the All-New SPIDER-GIRL! PAUL TOBIN & CLAYTON HENRY bring a tale of action & intrigue, and make a strong argument for why you can sometimes send a Spider-GIRL to do a Spider-MANs job Rated A $3.99