Adrianne Palicki ("Agents of S.H.I.E.L.D.") has been cast as one of the leads in Seth MacFarlane's upcoming -- and still untitled -- hourlong science-fiction/dramedy series on FOX.

According to Deadline, Palicki will play Kelly Grayson, the First Officer on a spaceship called the Orville, which is captained by her ex-husband, Ed (played by MacFarlane).

Set 300 years in the future, the series follows the exploits of the Orville's motley crew, and the cosmic challenges that come their way. In addition to MacFarlane and Palicki, the series will star "American Dad" alum Scott Grimes as Gordon, Ed's best friend and pilot of the Orville.

Since "Marvel's Most Wanted" -- the proposed "Agents of S.H.I.E.L.D." spinoff series that would star Palicki as Bobbi Morse/Mockingbird -- wasn't picked up, Palicki was freed up to work on MaFarlane's new show. Because of her commitment to the new series, there likely won't be much (if any) Bobbi in "Agents of S.H.I.E.L.D.'s" fourth season.

FOX has already ordered 13 episodes of the upcoming MacFarlane/Palicki-led series.